Biol 101 Individual Assignment 3 Instructions The Global Com

Biol 101individual Assignment 3 InstructionsThe Global Community Is Pl

BIOL 101 Individual Assignment 3 Instructions The global community is plagued by increasing incidence of lung cancer, colorectal cancer, breast and pancreatic cancers, prostate cancer, leukemia, non-Hodgkin lymphoma, liver, ovarian and esophageal cancers. Other types of cancer exist but are less frequent. What is the scientific community doing to attempt to eliminate the most common forms of cancer that are ravaging our society? 1. Be certain you’ve read your textbook’s chapter on cell division, specifically the last section on how cells become cancerous. This is context for completing Individual Assignment 3. 2. Watch the Presentation in Module/Week 4 entitled: “Ways to Fight Cancer”. Notice that the presentation outlines essentially 3 approaches to fighting cancer: a) reduction of cancer risks, b) correction of cancer genes, and c) destruction of cancerous tissue. 3. In the Individual Assigntment 3: 10 Discoveries in the War on Cancer document is a set of 10 scientists’ discoveries. Scan the discoveries briefly. Then open the assignment submission link in Module/Week 4. In the text box, number from 1 to 10 for the 10 discoveries listed below. 4. Now reflect carefully on the first discovery (#1). Would this discovery be more useful for (a) reducing cancer risks, (b) correcting/restoring cancer cells to normal, or (c) destroying cancerous tissue? After number 1 in your list, place in parentheses the letter representing the approach to fighting cancer that will best be served by this new discovery. (More than one approach may be served. But which is most likely to be helped most significantly ?) 5. Now repeat this analysis for each of the remaining 9 discoveries. Return to the “Ways to Fight Cancer” presentation as needed for additional perspective. When finished, your entire text box should be simple: a numbered (1-10) list of letters a, b or c. That’s it! Assignment done. 6. Ten points are granted for each correct association up to 6 correct. If you get any 6 correct out of 10, you get a perfect score (60 pts.) on the assignment. Your assignment is due by 11:59 p.m. (ET) on Monday of Module/Week 4. BIOL 101 Individual Assignment 3: 10 Discoveries in the War on Cancer 1. Scientists have always dissected lymph nodes nearby a cancerous tumor to see if the cancer has begun to spread to other areas of the body. The most obvious nearby lymph node is chosen. Scientists have discovered that in women with breast cancers that are 5 cm in diameter or smaller, nothing is gained by additional lymph node dissections in the axillary region (armpit) of the body. Dissecting the node nearest the tumor provides adequate information by itself. 2. Malignant brain tumors in adults are fast-growing cancers with median survival rates of 15 months, even with aggressive treatment. Researchers have been searching for genetic “signatures” (characteristic groups of cancer-causing genes) that could help in defining the kind of brain tumor the patient has. They hope to be better able to predict the course of the disease and the patient’s response to treatment. 3. Molecular geneticists have surveyed the entire human gene collection (the “genome”) in patients with neuroblastoma, a childhood cancer that forms in the adrenal glands and nerve tissue. Results of a genome-wide association study indicate that a specific region on human chromosome 1 is associated with the development of this cancer. This chromosome region contains a section of DNA that can vary in copy number from person to person, and neuroblastoma patients were more likely than control subjects to have fewer than normal copies of this DNA. 4. Tobacco smoking is the leading cause of preventable deaths worldwide. It is a risk factor for lung cancer and several other types of cancer. Results of analysis of the entire human gene collection (the “genome”) support some previous findings that a region of human chromosome number 15 contains one or more genes that are associated with smoking intensity (the number of cigarettes smoked per day) and the closely related trait of nicotine dependency. 5. Molecular biologists have developed a new sequence of human genes called an ankyrin insulator sequence. You place a new corrected or therapeutic gene within this sequence. Its role is to create an active area on a human chromosome where the new gene can work efficiently no matter what chromosome it lands on. 6. Molecular biologists have taken nanoparticle-sized spheres and used them to deliver a cell-killing toxin from bee venom to tumors in mice, substantially reducing tumor growth without harming normal body tissues. Nanoparticles are known to concentrate in solid tumors because blood vessels in tumors show “enhanced permeability and retention effect” or EPR. Hence, substances such as nanoparticles escape more readily from the bloodstream into tumors, and the generally poor drainage of lymph from tumors further helps trap the particles in tumor tissue. 7. Organic chemists are exploring structural variations of the organic compound avobenzone (1-(4-Methoxyphenyl)-3-(4- tert -butylphenyl) propane-1,3-dione) for inclusion in sunblock products. Avobenzone is known for its ability to absorb a broad spectrum of ultra-violet radiations including UVb light (known to enhance the frequency of basal cell and squamous cell carcinomas (skin cancers)) and UVa rays thought to increase the frequency of melanoma cancers. New variations in the structure of avobenzone are hoped to retain the ability to absorb harmful UV radiation while having an increased stability in the presence of that radiation. 8. Immunologists are investigating ways to destroy lymphocytes (white blood cells of the immune system) that have become cancerous (lymphomas). A current drug Rituximab contains antibodies that bind to the surfaces of these lymphocytes, setting them up for destruction by the cancer patient’s own immune system. They are currently seeking ways to modify the antibody’s structure so that it will attract the cancer patient’s “natural killer” (NK) cells to the lymphocytes. Success of this project will bring a multi-faceted immune response against lymphomas and hasten its destruction. 9. Biochemists are analyzing the many, many components of red meat (beef, pork) to determine which component, if any, will cause increased colorectal cancer rates in mice when the component is administered orally. Studies have shown that higher colorectal cancer rates in humans are associated with higher consumption rates of red meat. 10. Virologists are modifying lentiviruses as vectors for carrying proto-oncogenes into cancer-transformed cells in culture. They are developing this virus for inserting the ras proto-oncogene directly into its correct location in the genome. The correct ras gene will already be linked to human DNA to either side of it and complexed with a recombination enzyme that will insert it into its correct location within the human genome. At the same time, the recombination enzyme will excise the defective oncogenic form of ras. The cells in culture should again come under normal hormonal control and require extra-cellular signals in order to continue dividing.

Paper For Above instruction

The ongoing battle against cancer involves multiple scientific approaches aimed at understanding, preventing, and treating this complex set of diseases. The strategies can be broadly categorized into risk reduction, gene correction, and destruction of cancerous tissues. Analyzing recent discoveries provides insight into the most promising methods in the scientific community’s efforts to combat cancer effectively.

Discovery 1 relates to lymph node dissection in breast cancer patients. It emphasizes that for small tumors (≤5 cm), removing additional lymph nodes does not improve prognosis. This discovery primarily supports the approach of reducing unnecessary invasive procedures, which minimizes patient risk and side effects. Therefore, it aligns most with the strategy of reducing cancer risks through better diagnostic techniques and more precise treatment planning (approach a).

Discovery 2 deals with genetic signatures in malignant brain tumors, which can help define tumor types and predict disease progression. This discovery contributes mainly to correcting or restoring cancer cells to normal by understanding their genetic basis, enabling targeted therapies that could potentially revert malignant cells towards normalcy (approach b).

Discovery 3 involves genome-wide association studies in neuroblastoma patients, identifying specific chromosomal regions associated with cancer risk. This finding enhances risk assessment and prevention strategies, indirectly supporting reduction of risks by identifying susceptible individuals early (approach a). However, it also opens avenues for gene correction in personalized treatments, linking it to approach b.

Discovery 4 shows that certain genes on chromosome 15 are linked to smoking behavior, a major risk factor for lung cancer. This research primarily aims at risk reduction by understanding genetic predispositions influencing harmful habits (approach a).

Discovery 5 is about developing ankyrin insulator sequences to enable therapeutic genes to function correctly regardless of chromosomal integration site. This innovation facilitates gene correction and targeted therapies, supporting approach b.

Discovery 6 describes nanoparticle-mediated delivery of toxins to tumors, effectively destroying cancerous tissues while sparing normal tissue. This directly supports approach c, destruction of cancerous tissues through targeted nanotechnology.

Discovery 7 focuses on modifying sunblock ingredients to better absorb harmful UV rays responsible for skin cancers. This approach aligns with risk reduction by preventing DNA damage that leads to skin cancer, supporting approach a.

Discovery 8 involves immunological enhancement, where modified antibodies attract immune cells to destroy lymphomas. This approach supports destruction of cancerous tissue (approach c) by harnessing and amplifying the immune system’s ability to eliminate cancer cells.

Discovery 9 aims to identify carcinogenic components in red meat, potentially leading to dietary recommendations and risk reduction. This clearly aligns with approach a, reducing cancer risks by modifying lifestyle factors.

Discovery 10 involves genetic engineering of lentiviruses to correct proto-oncogene mutations, restoring cells’ normal growth controls. This directly pertains to approach b, correcting cancer-causing genetic alterations.

In summary, each discovery contributes differently to the three main approaches—risk reduction, gene correction, and tissue destruction. The most beneficial discoveries tend to support targeted, less invasive methods that aim to prevent cancer or restore normal cell functions, which collectively propel the fight against cancer forward.

References

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