Can You Complete This For Me Individual Assignment 3 Instruc

Can You Complete This For Meindividual Assignment 3 Instructionsthe Gl

The global community is plagued by increasing incidence of leukemia; non-Hodgkin lymphoma; lung, colorectal, breast, pancreatic, prostate, liver, ovarian, and esophageal cancers. Other types of cancer exist but are less frequent. What is the scientific community doing to attempt to eliminate the most common forms of cancer that are ravaging society?

1. Read the course textbook’s chapter on cell division, specifically the last section on how cells become cancerous.

2. Watch the Presentation in Module/Week 4 entitled “Ways to Fight Cancer.” Notice that the presentation outlines essentially 3 approaches to fighting cancer: a) reduction of cancer risks, b) correction of cancer genes, and c) destruction of cancerous tissue.

3. Open the “10 Discoveries in the War on Cancer” document in the Assignment Instructions folder. Scan the discoveries briefly. Then, open the assignment submission link in Module/Week 9. In the text box, number from 1 to 10 for the 10 discoveries.

4. Reflect carefully on discovery 1. Would this discovery be more useful for a) reducing cancer risks, b) correcting/restoring cancer cells to normal, or c) destroying cancerous tissue? After number 1 in your list, place in parentheses the letter representing the approach to fighting cancer that will best be served by this new discovery. (More than 1 approach may be served, but which is most likely to be helped most significantly?)

5. Repeat this analysis for each of the remaining 9 discoveries. Return to the “Ways to Fight Cancer” presentation as needed for additional perspective. When finished, your entire text box must be simple: a numbered (1–10) list of letters (a), (b) or (c).

The assignment is now complete. 6. Each correct association up to 8 correct answers is granted 7 points. If you get 9 or 10 out of 10, you get a perfect score (60 pts.) on the assignment. Submit this assignment by 11:59 p.m. (ET) on Monday of Module/Week 4.

Paper For Above instruction

The following analysis evaluates ten recent discoveries in the fight against cancer, determining which approach to cancer management they most effectively support: risk reduction, gene correction/restoration, or destruction of cancerous tissue. This assessment aligns with a broader understanding of current strategies and scientific advancements aimed at mitigating the global burden of cancer, including leukemia, lymphoma, and various carcinomas.

1. Gene Editing of Oncogenes via Recombination Enzymes

The first discovery involves the use of modified lentiviruses employing recombination enzymes to insert correct versions of proto-oncogenes, such as ras, into the human genome. This technique aims to excise defective oncogenic forms of these genes, restoring normal cellular function. As this approach directly targets the genetic basis of cancer, it is most aligned with the strategy of correcting or restoring cancer cells to their normal state (approach b). By rectifying the underlying genetic abnormalities, this discovery could significantly reduce the risk of cancer development and progression.

2. Identification of Genetic Signatures in Brain Tumors

This discovery centers on detecting genetic signatures within brain tumors, which helps in classifying tumor types and predicting their progression. While this knowledge assists in tailoring treatments, it primarily enhances prognosis and personalized therapy rather than directly reducing incidence or destroying tumors. Therefore, it supports the approach of correcting cancer by better understanding and potentially intervening on genetic levels (approach b). However, it also indirectly enables more precise destruction or risk mitigation.

3. Genetic Markers for Tobacco Dependence and Smoking Risk

Research identifying genetic regions associated with nicotine dependency provides a means to predict individual susceptibility to smoking addiction. This discovery facilitates preventative strategies, aligning most with the approach of reducing cancer risks. By identifying at-risk individuals before tobacco exposure, it supports preventive measures that can substantially lower future cancer incidence (approach a).

4. Antibody-Vector for Lighting Up Cancer Cells

The development of antibodies linked to gene expression vectors that target surface protein HER2 allows for specific identification and visualization of cancer cells. The ultimate goal involves delivering normal HER2 genes into mutant cancer cells to normalize their behavior. This approach is most suited to correcting or restoring cancer cells to normal (approach b), as it aims to modify the genetic content within cancer cells, potentially reverting malignant cells to a non-cancerous state.

5. Enhancing Immune Response Against Lymphomas

This discovery involves modifying antibodies to recruit natural killer (NK) cells for destroying lymphoma cells. This method directly destroys cancerous tissue, fitting squarely into the approach of tissue destruction (approach c). Amplifying the immune response to target and eliminate malignant lymphocytes exemplifies a direct intervention strategy against existing tumors.

6. Targeted Cancer Therapy Using Vemurafenib to Inactivate BRAF

The identification of a mutant BRAF kinase involved in cell division, and the development of specific drugs like vemurafenib, directly inhibit proliferative signaling pathways in melanoma and other cancers. This targeted therapy effectively induces apoptosis in cancer cells harboring the mutation, making this discovery primarily supportive of tissue destruction (approach c). It aims to eliminate existing cancer cells through molecular intervention.

7. Nanoparticle Delivery of Toxins to Tumors

This strategy employs nanoparticles to deliver bee venom toxins selectively to tumors based on their unique vascular properties. This approach directly destroys cancer cells without harming normal tissues, aligning explicitly with tissue destruction (approach c). The precision of nanoparticle targeting optimizes destruction while minimizing collateral damage.

8. Structural Variations of Avobenzone for Sun Protection

The exploration of avobenzone derivatives aims to improve UV radiation absorption in sunblock products, helping prevent skin cancers caused by UV exposure. While preventive in nature, this discovery supports risk reduction (approach a) by decreasing environmental factors that contribute to skin carcinogenesis, although its primary aim is to improve protective formulations.

9. Components of Red Meat and Colorectal Cancer Risk

The analysis identifying specific red meat components linked with increased colorectal cancer rates informs dietary recommendations. This discovery is aligned with reducing cancer risks (approach a), as it emphasizes preventive dietary modifications to lower disease incidence.

10. Insulator Sequences for Gene Placement

The development of human ankyrin insulator sequences enables more efficient gene therapy by ensuring proper gene expression regardless of chromosomal landing sites. This supports the approach of correcting or restoring cancer genes (approach b) by improving gene therapy techniques for potential cancer treatments.

Conclusion

In summary, these ten discoveries encompass a spectrum of strategies in cancer control, from prevention and risk assessment to genetic correction and targeted destruction. Advances such as gene editing and insulator sequences promote correction of cancerous cells, while therapies like nanoparticle toxins and kinase inhibitors focus on directly destroying tumor tissue. Understanding the most appropriate strategy for each discovery enhances the development of effective, personalized cancer treatments, ultimately contributing to reducing the global cancer burden.

References

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• Chung, H. M., et al. (2020). Advances in cancer immunotherapy. Journal of Clinical Oncology, 38(28), 3242-3245.
• Gordon, L. I., & Kraus, W. L. (2019). Targeting kinase BRAF in melanoma. Nature Reviews Drug Discovery, 18(5), 搬515–517.
• Hann, S., & O’Connor, R. (2018). Genetic signatures in brain tumors. Cancer Cell, 33(4), 543-546.
• Kim, S. T., & Weisz, J. (2017). Nanoparticle delivery systems in oncology. Trends in Pharmacological Sciences, 38(6), 448-463.
• Malik, E., & Thorne, N. (2016). Sun protection and skin cancer prevention. Journal of Dermatological Science, 82(2), 123-130.
• Sharma, R., et al. (2021). Genetic predisposition to smoking and addiction. Nature Genetics, 53(1), 28–36.
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