Hello, This Work Is On Advanced Pathophysiology. ✓ Solved

Hello This Work Is On Advanced Pathophysiology It Must Have A Minimu

This work is on advanced pathophysiology, focusing on the hormonal regulation of pancreatic secretions in response to chyme entering the duodenum. The question pertains to which hormone stimulates the release of pancreatic fluids rich in bicarbonate ions when highly acidic chyme enters the duodenum.

In the process of digestion, the entry of acidic chyme from the stomach into the duodenum triggers several hormonal responses to neutralize the acid and facilitate the digestive process. Among the hormones listed—gastrin, secretin, cholecystokinin, and histamine—secretin is the primary hormone responsible for stimulating the pancreas to secrete bicarbonate-rich fluid. This secretion is crucial in neutralizing gastric acid, protecting the intestinal mucosa, and providing an optimal pH for pancreatic enzymatic activity.

Secretin is produced by S cells in the mucosa of the duodenum in response to the presence of acidic chyme. When the acidic content stimulates the S cells, secretin is released into the bloodstream, signaling the pancreatic acinar cells to increase bicarbonate secretion. The bicarbonate ions serve to elevate the pH of the chyme, creating a more neutral environment suitable for digestive enzymes to function effectively. This process is essential for maintaining the overall digestive balance and ensuring proper nutrient absorption.

Other hormones in the list have distinct roles: gastrin mainly stimulates gastric acid secretion from the stomach; cholecystokinin (CCK) primarily induces gallbladder contraction and pancreatic enzyme secretion; histamine enhances gastric acid production. However, in the context of neutralizing acid in the duodenum, secretin is the key hormone responsible for stimulating bicarbonate secretion from the pancreas, thus making it the correct answer to the question.

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