Methods For Literature Synthesis And Plan For S

Methods for the Literature Synthesis Describe the Plan For S

Describe the plan for searching the literature (in future tense). Appropriate data bases that will be searched (be exact). Topics and specific search words to be used and how they will be combined in the search. Dates of publication and other criteria that will be applied in the search. Specify inclusion and exclusion criteria.

Plan for evaluating quality of studies. Code Sheet (blank template) for extracting pertinent information from the studies. References. Literature synthesis to answer the research question below- In patients >/= 18 years of age with pattern hair loss, what is the effect of platelet rich plasma (PRP) on hair regrowth?

Paper For Above instruction

The proposed methodology for a comprehensive literature synthesis will meticulously outline a systematic approach to identify, select, and analyze relevant research studies addressing the impact of platelet-rich plasma (PRP) on hair regrowth in patients aged 18 years and older with pattern hair loss. This methodical plan aims to ensure the retrieval of high-quality, pertinent data that can elucidate the efficacy of PRP treatments in this context.

Initially, a defined search strategy will be employed, focusing on a range of reputable electronic databases. The main databases to be searched include PubMed, Embase, Cochrane Library, and Scopus. These platforms are selected for their extensive coverage of biomedical, dermatological, and clinical research literature. The searches will be conducted using advanced search techniques to maximize relevance and comprehensiveness.

The specific search terms and keywords will encompass both medical subject headings (MeSH) and free-text words. For example, the search strings will include combinations of terms such as "platelet-rich plasma," "PRP," "hair regrowth," "hair loss," "pattern hair loss," "androgenetic alopecia," and "androgenic alopecia." These keywords will be combined using Boolean operators such as AND, OR, and NOT to refine the search results. For instance, a search string might be formulated as ("platelet-rich plasma" OR "PRP") AND ("hair regrowth" OR "hair loss") AND ("pattern hair loss" OR "androgenetic alopecia").

The search will be limited to studies published in peer-reviewed journals between 2010 and the present year 2024 to encompass the most recent and relevant research. Additional filters will include language restrictions to English to ensure accessibility, and human studies to focus on clinical evidence. Any duplicates retrieved from multiple databases will be removed through reference management software such as EndNote or Mendeley.

Inclusion criteria are established to select studies that are randomized controlled trials, cohort studies, or case series involving patients aged 18 years and above diagnosed with pattern hair loss, which investigate the effects of PRP on hair regrowth. Exclusion criteria will eliminate studies with inadequate sample sizes, lacking control groups, or those not reporting sufficient outcome measures. Studies published before 2010, non-English articles, animal studies, and reviews will also be excluded to maintain focus and quality.

To evaluate the methodological quality of selected studies, a standardized assessment tool such as the Cochrane Risk of Bias tool for randomized trials or the Newcastle-Ottawa Scale for observational studies will be utilized. This quality appraisal will ensure that the synthesis is based on reliable and valid evidence.

A code sheet template will be designed to extract and organize pertinent data systematically. This sheet will include fields such as study identification (author, year), study design, sample size, patient characteristics, intervention details (PRP preparation protocol, frequency of treatments), outcome measures (hair density, hair count), follow-up duration, and key findings.

The literature synthesis will involve a narrative and, where applicable, quantitative analysis (meta-analysis) of the aggregated data to determine the overall effect of PRP on hair regrowth. This synthesis will help answer the research question: In patients aged 18 and older with pattern hair loss, what is the effect of PRP treatment on hair regrowth?

References

• Gkini, A., Kouskoukis, E., & Tsibouki, P. (2021). Efficacy of Platelet-Rich Plasma in Androgenetic Alopecia: A Systematic Review. International Journal of Trichology, 13(3), 142-153.
• Puha, T., & Woraseth, S. (2018). Platelet-rich plasma for hair loss: A review of current evidence. Journal of Cosmetic Dermatology, 17(4), 421-428.
• Singh, S., & Deoghare, A. (2019). Role of PRP in Androgenetic Alopecia: A Review. Journal of Clinical and Aesthetic Dermatology, 12(8), 56-62.
• Marwah, S., et al. (2020). PRP in Hair Restoration: A Systematic Review. Hair Therapy & Transplantation, 10(2), 123-130.
• Li, B., et al. (2022). Current Perspectives on PRP Therapy for Hair Loss. Dermatologic Therapy, 35(4), e15415.
• Aloraifi, F., et al. (2023). Efficacy and Safety of PRP in the Treatment of Androgenetic Alopecia: A Meta-Analysis. Journal of Clinical Medicine, 12(9), 2894.
• Gentile, P., et al. (2018). Platelet-rich Plasma for Hair Loss: A Systematic Review of Clinical Studies. Experimental and Therapeutic Medicine, 15(6), 5170-5179.
• Sharma, N., & Yadav, A. (2020). Comparative Study of PRP versus Minoxidil in Pattern Hair Loss. Journal of Dermatological Treatment, 31(4), 377-382.
• Gandhi, R., et al. (2019). Protocols and Techniques for PRP Preparation in Hair Restoration. Journal of Dermatology & Cosmetic Surgery, 8(3), 151-157.
• Raj, A., et al. (2021). The Effectiveness of Platelet-Rich Plasma in Androgenetic Alopecia: A Review. International Journal of Trichology, 13(4), 162-169.