Chapter 10: Von Willebrand Disease

Chapter 10 Von Willebrand Diseasevon Willebrand Disease Vwd Is The
Von Willebrand disease (VWD) is one of the most common inherited bleeding disorders, characterized by a deficiency or dysfunction of the von Willebrand factor (VWF), which plays a crucial role in platelet adhesion and carries coagulation factor VIII (Favaloro, 2017). The study highlighted in the post underscores the heightened risk of postpartum hemorrhage (PPH) among women with VWD, especially those with type three, which presents with the most severe deficiency of VWF (Govorov et al., 2016). The research underscores the importance of accurately diagnosing VWD prior to delivery, as untreated women experience higher rates of significant blood loss. Moreover, low serum levels of FVIII correlate with increased bleeding, emphasizing the need for targeted hematologic management (Govorov et al., 2016). Future research should explore optimal hemostatic treatments and develop clinical guidelines tailored for pregnant women with VWD to mitigate PPH risks. For advanced nursing practice, understanding the variability among VWD subtypes and treatment options is vital to providing comprehensive care and education to affected women. Early identification and personalized management strategies could substantially reduce hemorrhagic complications during childbirth. Overall, integrating hematologic knowledge into obstetric care can improve outcomes for women with VWD.
References
Favaloro, E. J. (2017). Von Willebrand disease: A review of current laboratory approaches. Journal of Thrombosis and Thrombolysis, 44(3), 399-407.
Govorov, K., et al. (2016). Postpartum hemorrhage in women with von Willebrand disease: A retrospective study. Blood Coagulation & Fibrinolysis, 27(7), 723-729.