Disorders Of Skin Integrity And Function Leonard Works In Th

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Disorders Of Skin Integrity And Functionleonard Works In The Agricultu Disorders of Skin Integrity and Function Leonard works in the agriculture industry and raises beef cattle. At 60 years old, he has spent most of his life working outdoors harvesting hay and tending to his herds. His wife was the first to notice a change in his skin. One day, after taking off his shirt, she noticed a significant change in the mole he had on his right shoulder. It not only was darker but was moist and appeared to have been bleeding at one point. Surrounding the mole, his skin was red. His wife remembered hearing stories of Leonard working on his father’s farm, spending long hours out in the hot sun even though his father had gone into the barn to work during the hottest part of the day. She insisted he go to the family physician to have it examined (Chapter 52, Learning Objectives 10 and 11). Leonard’s physician performed a biopsy on the lesion and told Leonard he suspected the growth may be malignant melanoma. What cells are affected in this form of skin cancer? How might his childhood exposures to the sun predispose him to this form of cancer? How do UVA and UVB rays contribute to the process of oncogenesis in skin cells? The mole on Leonard’s shoulder was a nevocellular nevus. What are the cellular composition and appearance of this type of mole before it underwent malignant change? Instructions: Your primary post should be at least 200 words long and should include reference to the textbook or another course resource using APA 7th edition format.

Dr. Jack HW Helper · Accepted Answer

The case of Leonard underscores the importance of understanding skin cancers, particularly malignant melanoma, which affects melanocytes—the pigment-producing cells in the epidermis. Malignant melanoma originates from these melanocytes, which are primarily located in the basal layer of the epidermis. These cells become malignant when genetic mutations occur, leading to uncontrolled proliferation and potential metastasis (Guy et al., 2015). In Leonard's case, the changes observed in the mole—darker coloration, moist appearance, bleeding, and surrounding erythema—are characteristic signs of malignant transformation. Prolonged and cumulative sun exposure during childhood significantly predisposes individuals like Leonard to melanoma later in life. Ultraviolet (UV) radiation from sunlight is a major environmental risk factor for skin cancer, with UVA and UVB rays playing distinct roles in oncogenesis (El Ghissassi et al., 2012). UVB radiation causes direct DNA damage by inducing the formation of pyrimidine dimers, which can result in mutations if not properly repaired. These mutations often occur in tumor suppressor genes like p53, disrupting cell cycle regulation and apoptosis (Afaq & Mukhtar, 2007). UVA radiation, though less energetic, penetrates deeper into the dermis and generates reactive oxygen species that indirectly damage DNA and promote genetic mutations, as well as immunosuppression, which facilitates cancer development (Rasol et al., 2012). Children and young adults exposed to significant UV radiation develop sunburns and cumulative DNA damage, increasing their lifetime risk. In Leonard's scenario, long-term outdoor work under intense sunlight likely led to considerable UV exposure, fostering the molecular changes necessary for melanoma development. Moreover, the presence of a nevocellular nevus (a mole composed of melanocytes) exemplifies a benign proliferation of melanocytes, typically symmetrical with even borders and uniform color before malignant t

Disorders Of Skin Integrity And Function Leonard Works In Th

Disorders Of Skin Integrity And Functionleonard Works In The Agricultu

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Disorders Of Skin Integrity And Functionleonard Works In The Agricultu

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