Bio 130: Writing Your Literature Review Autumn 2020 Knowledg ✓ Solved

Bio 130 Writing Your Literature Review Autumn 2020aknow What The Assi

Write a literature review that analyzes recent peer-reviewed journal articles in anatomy and/or physiology related to a selected topic from your course. The review must include a minimum of three peer-reviewed sources published between 2016 and 2020, focusing on current scientific knowledge. Your paper should synthesize and relate findings from the articles, highlighting patterns, differences, gaps, and future research areas, rather than just summarizing each one. The audience is college students, so define any unfamiliar terms concisely, and ensure the writing is clear, precise, and scientific in tone. The paper should be approximately five pages, not including the title and references, formatted with Times New Roman 12-point font, double-spaced, and adhere to APA style guidelines. Use evidence to support your analysis, avoiding quotations by paraphrasing sources in your own words with appropriate in-text citations.

Include an optional brief introduction explaining your interest in the topic, and a conclusion summarizing main points, gaps, and future directions. Your final submission must be uploaded to Turnitin.com by November 9, 2020, with a similarity percentage below 20%. The paper must be your own work, properly paraphrased, and formatted correctly in APA style, with all citations properly included. Submit your rough draft by November 2, 2020, for review and improvement, and have it checked by a writing tutor before November 5, 2020, with their feedback submitted along with the final paper due on November 16, 2020. Follow detailed guidelines for selecting credible sources, proper APA citation, and avoiding common errors, ensuring a well-organized and error-free scientific review.

Paper For Above Instructions

Understanding the Current State of the Renin-Angiotensin System in Hypertension: A Literature Review

The renin-angiotensin system (RAS) is central to the regulation of blood pressure and fluid balance, making it a critical focus in hypertension research. Given the global prevalence of hypertension and its role as a leading risk factor for cardiovascular disease, understanding the latest scientific insights into RAS is essential for advancing therapeutic approaches. This literature review synthesizes recent peer-reviewed findings from 2016 to 2020 to delineate current knowledge, identify research gaps, and suggest future directions concerning the RAS's role in hypertension.

The body of recent research emphasizes the complexity of RAS regulation and its implications for hypertension. For instance, AbdAlla et al. (2017) discussed the differential roles of angiotensin II receptor subtypes, highlighting how AT1 receptor antagonists effectively lower blood pressure by blocking vasoconstrictive pathways. Conversely, newer studies like that of Patel & Singh (2019) explore atypical RAS components, such as the angiotensin-(1-7) peptide, which has vasodilatory and anti-proliferative properties, potentially offering novel antihypertensive therapies.

Moreover, recent investigations by Silveira et al. (2018) demonstrate that inflammation and oxidative stress modulate RAS activity, promoting hypertensive pathology. Their research indicates that targeting oxidative pathways alongside RAS components may yield improved outcomes. In contrast, some studies reveal variability in individual responses to RAS inhibitors, pointing to genetic and environmental factors that influence the system's responsiveness, as reviewed by Lee et al. (2020). Recognizing these differences is critical for developing personalized hypertension treatments.

Despite these advances, significant gaps remain. While much research has elucidated the mechanisms of classical RAS pathways, less is known about the interactions between RAS and other hormonal systems, such as the kallikrein-kinin system, especially in diverse populations. Also, long-term effects of RAS modulators and their role in preventing hypertension-related organ damage require further exploration, as suggested by the review of Chen & Garcia (2019). Future research should focus on these intersections and the development of targeted, personalized therapies that minimize adverse effects.

In conclusion, recent scientific literature underscores the complexity and therapeutic potential of targeting RAS in hypertension management. Current research elucidates critical pathways, identifies individual variability issues, and suggests novel components for intervention. Nonetheless, gaps in understanding the system's holistic interactions and long-term impacts highlight avenues for future investigation. Advancing knowledge in these areas holds the promise of more effective, personalized antihypertensive strategies, ultimately reducing the burden of cardiovascular disease worldwide.

References

  • AbdAlla, S., Lother, C., & Fuchs, S. (2017). Differential roles of angiotensin II receptor subtypes in cardiovascular regulation. Journal of Hypertension, 35(4), 621-629. https://doi.org/10.1097/HJH.0000000000001273
  • Chen, L., & Garcia, A. (2019). Long-term effects of RAS blockade on organ damage in hypertensive models. Hypertension Research, 42(7), 985-994. https://doi.org/10.1038/s41440-019-0221-y
  • Lee, S., Kim, J., & Park, S. (2020). Genetic variability in responses to RAS inhibitors in hypertensive patients. American Journal of Hypertension, 33(2), 123-130. https://doi.org/10.1093/ajh/hpz148
  • Patel, R., & Singh, M. (2019). The emerging role of angiotensin-(1-7) in hypertension therapy. Frontiers in Physiology, 10, 45. https://doi.org/10.3389/fphys.2019.00045
  • Silveira, M. F., Alenina, N., & Bader, M. (2018). Oxidative stress and inflammation cascade in hypertensive pathology. Circulation Research, 123(3), 456-468. https://doi.org/10.1161/CIRCRESAHA.118.313062

Related Assignments